Before 30 Years and After 30 Years

Allosteric Receptors after 30 Years

Monoclonal and recombinant antibodies, 30 years after ...

In 1975, the hybridoma technology provided, for the first time, an access to murine monoclonal antibodies. During the two following decades, their high potential, as laboratory tools, was rapidly exploited, but in vivo applications were still very limited. Nowadays, antibodies, omnipresent in both diagnostic and research domains, are largely invading the domain of therapy. A wide array of novel...

Adrenalectomy and pancreatectomy--30 years after.

In the second edition of their monograph Soskin and Levine1 discussed two theories about diabetes that had developed before 1930. One held that diabetes was due to the overproduction of glucose; the other that diabetes was the result of the nonutilization of glucose. Both concepts recognized the dominant role of insulin deficiency based on the work of von Mering and Minkowski.' In 1931 Houssay ...

Adaptionism-30 years after Gould and Lewontin.

Gould and Lewontin's 30-year-old critique of adaptionism fundamentally changed the discourse of evolutionary biology. However, with the influx of new ideas and scientific traditions from genomics into evolutionary biology, the old adaptionist controversies are being recycled in a new context. The insight gained by evolutionary biologists, that functional differences cannot be equated to adaptiv...

Computer Engineering 30 Years After the IBM

ften in our hurry to create the future in computer engineering, we ignore lessons from past projects. One project that offers interesting insights, the IBM System/360 Model 91, recently celebrated the 30th anniversary of its first shipment. The largest member of the series based on IBM’s most enduring and influential computer architecture, this machine owed much to its predecessors. Together, t...